Native Cartilage Oligomeric Matrix Protein, recombinant human (rhCOMP)

Product number #10020

Affinity purified recombinant human COMP in PBS, sterile filtered (0.2 µm)

Cartilage Oligomeric Matrix Protein (COMP) Induced Arthritis in the C57BL/6 Mouse - The Methodology

Genetically modified mouse strains have most often been developed on the C57BL/6 genetic background, which has restricted their use for rheumatology research due to the lack of reliable model for rheumatoid arthritis (RA) for this strain. The C57BL/6 mice possess the MHC class II haplotype H‑2b, which has so far prohibited induction of any known model for rheumatoid arthritis.

        Cartilage Oligomeric Matrix Protein (COMP) Induced Arthritis is a new model for rheumatoid arthritis in the C57BL/6 mouse. It is established by immunization by native COMP and leads to severe arthritis with characteristic T and B cell responses against defined COMP peptides.

COMP induced arthritis provides disease model to study the immune priming, the effector and chronic phases of arthritis and can be used for efficient induction of arthritis in the C57BL/6J mice.

       The key for successful arthritis experiments to solve your research questions is a thorough understanding of the model with its advantages and limitations.

Download This White Paper to Understand:

·         How to induce experimental arthritis in your C57BL/6 mouse

·         The expected severity and incidence of the disease

·         Differences between COMP models using IFA or CFA as adjuvant

·         Importance of the conformation of COMP for the model

·         The methodology to follow arthritis development ex vivo and in vitro

·         The benefits and limitations of COMP induced arthritis

Keywords: rheumatoid arthritis, cartilage oligomeric matrix protein, C57BL/6 mice

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