Affinity purified chimeric human-mouse monoclonal anti- collagen type II (COL2A1) antibody clone CIIC1 in PBS
| 100 µg / 0.1 mL | 249 € |
| 1 mg / 1 mL | 1,200 € |
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Anti-COL2A1 Antibody (CIIC1) binds to the triple helical C1 epitope on collagen type 2 (CII), but not when the epitope is double-citrullinated (Cit-Cit). CIIC1 can be used in studies of collagen citrullination together with mouse Anti-citrullinated COL2A1 Antibody (ACC4, Product number #10190). Binding specificity to triple helical C1 peptide epitopes was determined by bead-based flow immunoassay as median fluorescence intensity (MFI).
Description
Affinity purified chimeric human-mouse monoclonal anti collagen II (COL2A1) antibody clone CIIC1 in PBS. The CIIC1 antibody binds specifically to the C1 epitope on triple helical type 2 collagen. This clone has been used in applications including ELISA, immunohistochemistry (IHC) and in vivo functional studies such as collagen antibody induced arthritis1-3.
Target with alternative names
COL2A1, Collagen alpha-1(II) chain, CII, Col II. UniProt: P28481.
The antibody clone CIIC1 originates from B cells of collagen type 2 immunized DBA/1 mice1-3.
Epitope
The CIIC1 antibody binds to the C1 epitope (position 358–363; GARGLT) on triple helical type 2 collagen4,5.
Species reactivity
Mouse, rat, chicken, horse, baboon
Isotype
Human IgG1, κ
Concentration
1 mg/ml
Sizes available
100µg and 1mg
Supplied in
PBS
Storage
Centrifuge briefly prior to opening vial. Store at +4 °C short term (1-2 weeks). Aliquot and store at ‑20 °C long term. Avoid repeated freeze/thaw cycles.
It is recommended the user determines the optimal dilution for their application. The typical starting working dilution for IHC is 1:100 and 1:1000 for ELISA.
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
References
